What is an epithelial cells in urine test?
An epithelial cells in urine test is a diagnostic tool used to detect the presence and quantity of epithelial cells in urine. These cells naturally shed from the urinary tract, but an excessive amount may indicate underlying health conditions such as urinary tract infections (UTIs), kidney disease, or chronic inflammation (Burgess & Grayland-Leech, 2024).
Epithelial cells line the body's surface, acting as a protective barrier. There are three types of epithelial cells, these are listed below (Burgess & Grayland-Leech, 2024):
- Squamous epithelial cells:These are the largest type of epithelial cells and are primarily found in the vagina, urethra, and external genitalia. Their presence in urine is usually not a concern unless found in high quantities, which may indicate contamination or infection.
- Transitional epithelial cells: These are located between the renal pelvis and urethra and are commonly shed due to natural turnover. However, large numbers may suggest urinary tract infections, bladder inflammation, or even malignancies.
- Renal epithelial cells: These originate from the kidneys and should be minimal or absent in healthy urine samples. The presence of renal epithelial cells may indicate kidney damage, chronic kidney disease (CKD), or acute tubular injury.
An epithelial cells in urine test involves collecting a midstream urine sample, which is analyzed under a microscope. A urinalysis will assess:
- The number and type of epithelial cells present
- Red blood cells, white blood cells, and protein levels
- Signs of infection, kidney disease, or urinary tract damage
Healthcare providers then record the results in an Epithelial Cells in Urine Test Report, which summarizes the findings and any relevant information for healthcare providers to diagnose and treat the patient properly.










