Insulin Resistance ICD-10-CM Codes

Insulin Resistance ICD-10-CM Codes

Learn about ICD-10 codes for insulin resistance, including E88.810–E88.819, billing guidance, symptoms, causes, and treatment for metabolic disorders.

By Wynona Jugueta on Aug 8, 2025.

Fact Checked by Ericka Pingol.

Use Code

What are Insulin Resistance ICD-10-CM Codes?

Insulin resistance is a metabolic condition in which the body's fat, muscle, and liver cells respond poorly to insulin, leading to elevated blood glucose levels. In the ICD-10-CM coding system, this condition has traditionally been represented under E88.81 – Metabolic Syndrome, a billable code that also covers broader metabolic disorders.

Here are the current ICD-10-CM codes related to insulin resistance:

  • E88.810 – Metabolic syndrome
  • E88.811 – Insulin resistance syndrome, Type A
  • E88.818 – Other insulin resistance
  • E88.819 – Insulin resistance, unspecified

These will enable clinicians to code not only for insulin resistance but also for its associated conditions and manifestations, including obesity, diabetes mellitus, hyperglycemia, and hypertension.

Which Insulin Resistance ICD-10-CM Codes are billable? 

All four codes listed above are ICD-10 billable codes. These codes support medical billing and reimbursement processes, particularly when insulin resistance is diagnosed alongside other chronic diseases or hormone disorders such as type 2 diabetes, dysmetabolic syndrome, or diabetes mellitus with associated manifestations.

Clinical information

  • Insulin resistance is when fat, muscles, and liver cells don’t respond well to insulin. The result is the cells’ inability to take or store glucose from one’s blood and the pancreas’ compensation of making more insulin to lower one’s blood glucose levels. 
  • When unchecked, insulin resistance increases the risk of a patient being overweight, having high triglycerides, and having high blood pressure. 
  • Though the cause of insulin resistance has yet to be found, significant factors are excess weight, diet, certain medications, and physical inactivity. 
  • Usually, those with insulin resistance don’t exhibit any symptoms. If they do, especially those with prediabetes, they may have acanthosis nigricans or darkened skin/skin tags in the armpits and back/sides of the neck. 
  • Practitioners will have the patient undergo blood tests to check if the patient has insulin resistance or, specifically, pre-diabetes. They will usually check the results of their glucose, lipids, and A1c. 
  • Treatment is mainly lifestyle modification wherein the patient must eat a healthier diet, be more physically active, and lose excess weight.

Synonyms include:

  • Insulin Resistance - Type A
  • Insulin Resistance - Type B
  • Insulin receptor defect
  • Glucose-galactose malabsorption

Commonly asked questions

Use an Insulin Resistance ICD-10 code when a patient has documented evidence of insulin resistance, metabolic syndrome, or related clinical features such as hyperglycemia, elevated insulin levels, or associated metabolic conditions. Coding should reflect whether the condition is specified (e.g., Type A syndrome) or unspecified, based on the provider's documentation.

Yes, the ICD-10 diagnosis codes for insulin resistance—including E88.810, E88.811, E88.818, and E88.819—are billable for medical services. These codes support documentation and reimbursement for care related to metabolic syndrome and insulin resistance disorders.

Common treatments for insulin resistance include lifestyle modifications, such as adopting a healthier diet, engaging in regular physical activity, and losing weight. In some cases, medications such as metformin or drugs that target glucose regulation may also be prescribed to enhance insulin sensitivity.

Related ICDs

EHR and practice management software

Get started for free

*No credit card required

Free

$0/usd

Unlimited clients

Telehealth

1GB of storage

Client portal text

Automated billing and online payments