Parathyroidectomy ICD-10-CM Codes

Parathyroidectomy ICD-10-CM Codes

Learn the ICD-10-CM codes for parathyroidectomy, including diagnosis details, synonyms, and billability in this short guide.

By Audrey Liz Perez on Aug 8, 2025.

Fact Checked by Gale Alagos.

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What ICD-10 codes are used for parathyroidectomy? 

Parathyroidectomy is performed to treat conditions like primary hyperparathyroidism, secondary hyperparathyroidism, and parathyroid hyperplasia, all of which involve overproduction of parathyroid hormone by one or more of the four parathyroid glands. This overactivity can result in high blood calcium levels, kidney stones, and other metabolic complications.

In most cases, the goal is to remove the overactive gland while preserving the remaining parathyroid glands to keep calcium levels within a healthy range. Care is taken to avoid damaging the nearby thyroid gland, and long-term follow-up may be needed to monitor for recurrence or too much parathyroid hormone production. Parathyroidectomy remains the most definitive way to treat primary hyperparathyroidism when medical management is ineffective.

ICD-10-CM codes help document these conditions before or after parathyroid surgery, including cases treated with minimally invasive surgery or bilateral neck exploration.

These are the ICD codes used for Parathyroidectomy:

E21.0 – Primary hyperparathyroidism

Used when a single or multiple overactive parathyroid glands cause excess parathyroid hormone, often requiring parathyroidectomy.

E21.1 – Secondary hyperparathyroidism, NEC

Refers to parathyroid overactivity due to another medical condition (e.g., chronic kidney disease), not a gland disorder itself.

E21.2 – Other hyperparathyroidism

Covers rare cases like tertiary or refractory hyperparathyroidism, often requiring bilateral exploration.

E21.3 – Hyperparathyroidism, unspecified

Used when the type of hyperparathyroidism is not clearly defined in the documentation.

E21.4 – Other specified disorders of parathyroid gland

Applied to uncommon or complex parathyroid disorders not classified elsewhere.

E21.5 – Disorder of parathyroid gland, unspecified

A general code for unspecified parathyroid gland issues; may be used preoperatively.

D35.1 – Benign neoplasm of parathyroid gland

Used when an adenoma is the cause of overactive parathyroid hormone production.

E89.2 – Postprocedural hypoparathyroidism

This is for patients who develop low calcium or hypocalcemia after parathyroidectomy.

E89.89 – Other postprocedural endocrine complications

Captures additional endocrine/metabolic complications after parathyroid surgery.

Which parathyroidectomy ICD codes are billable? 

Yes, all the ICD codes mentioned above are valid and billable for reimbursement purposes when supported by proper clinical documentation.

Clinical information

  • Indications: Parathyroidectomy is indicated for conditions such as primary hyperparathyroidism, secondary hyperparathyroidism, parathyroid hyperplasia, and benign neoplasms of the parathyroid glands.
  • Surgical approaches: Depending on the underlying condition and gland involvement, techniques include traditional parathyroidectomy, minimally invasive parathyroidectomy, and bilateral neck exploration.
  • Preoperative evaluation: Patients undergo imaging tests to localize the overactive gland(s) preoperatively and blood tests to assess parathyroid hormone and blood calcium levels.
  • Postoperative care: Management may involve calcium supplements to address low calcium levels and monitoring for postprocedural hypoparathyroidism. Patients are advised to eat soft foods post-surgery and watch for symptoms like sore throat, numbness, or tingling.

Synonyms include:

  • Parathyroid gland removal
  • Parathyroid surgery
  • Excision of parathyroid gland
  • Removal of overactive parathyroid gland
  • Parathyroidectomy surgery
  • Minimally invasive parathyroidectomy​

Commonly asked questions

You can use the parathyroidectomy-related ICD codes once you’ve finalized the issue with the patient’s parathyroid gland and once the patient has consented to a parathyroidectomy as the best treatment for it.

Yes, all of the specific codes mentioned in this guide are billable.

It means that the practitioner has diagnosed an issue with the patient’s parathyroid glands, recommended a parathyroidectomy, and obtained the patient’s consent to do move forward with the treatment.

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