E78.2 – Mixed hyperlipidemia

E78.2 diagnosis code: Mixed hyperlipidemia

The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) diagnosis code E78.2 is used for mixed hyperlipidemia. This condition, under "disorders of lipoprotein metabolism and other lipidemia," is characterized by high levels of both cholesterol and triglycerides in the blood, which can raise the risk of heart disease. Medical providers use ICD-10-CM codes like E78.2 for accurate diagnosis, documentation, and insurance billing.

This code applies to:

• Broad- or floating-betalipoproteinemia
• Combined hyperlipidemia, not otherwise specified (NOS)
• Elevated cholesterol with elevated triglycerides, not elsewhere classified (NEC)
• Fredrickson's hyperlipoproteinemia, type IIb or III
• Hyperbetalipoproteinemia with prebetalipoproteinemia
• Hypercholesteremia with endogenous hyperglyceridemia
• Hyperlipidemia, group C
• Tubo-eruptive xanthoma
• Xanthoma tuberosum

Meanwhile, type 1 excludes cerebrotendinous cholesterosis [van Bogaert-Scherer-Epstein] (E75.5) and familial combined hyperlipidemia (E78.49).

These inclusion and exclusion terms help support accurate diagnosis coding and documentation.

Is E78.2 billable?

Yes, ICD-10-CM code E78.2 is a billable and specific diagnosis code for reimbursement purposes. Healthcare providers can use this to indicate a confirmed diagnosis of mixed hyperlipidemia on claims submitted to insurance companies.

Clinical information

• Mixed hyperlipidemia is a type of familial lipid metabolism disorder where cholesterol and triglycerides are elevated in the blood. This condition involves the abnormal processing of lipids, leading to increased levels of low-density lipoprotein (LDL) cholesterol and triglycerides. These imbalances can develop due to inherited genetic traits that affect how fats are metabolized in the body.
• This condition poses a significant risk for atherosclerosis and heart disease. When cholesterol and triglyceride levels remain high, fatty deposits can build up in the arteries, narrowing them over time. This increases the risk of cardiovascular events such as heart attacks, strokes, and peripheral artery disease.
• Mixed hyperlipidemia can be hereditary or caused by uncontrolled diabetes, hypothyroidism, kidney disease, or certain medications. While many cases are inherited, some people develop the condition due to other health problems that affect lipid metabolism.
• Management involves a combination of diet modification, regular exercise, and medicine to control lipid levels. A heart-healthy diet low in saturated fats and refined sugars, along with consistent physical activity, helps improve cholesterol and triglyceride levels.
• It is often asymptomatic and diagnosed through routine blood tests. Since mixed hyperlipidemia usually doesn't cause noticeable symptoms, it may go undetected without regular screening.

Synonyms include

• Diabetes type 1 with hyperlipidemia
• Diabetes type 2 with hyperlipidemia
• Eruptive xanthoma
• Hyperlipidemia, mixed (high blood fats)
• Mixed hyperlipidemia associated with type 1 diabetes mellitus
• Mixed hyperlipidemia associated with type 2 diabetes mellitus
• Mixed hyperlipidemia due to type 1 diabetes mellitus
• Mixed hyperlipidemia due to type 2 diabetes mellitus
• Tuberous xanthoma
• Xanthoma tuberosum

Other ICD-10 codes commonly used for disorders of lipoprotein metabolism and other lipidemia

• E78.01: Familial hypercholesterolemia
• E78.1: Pure hyperglyceridemia
• E78.3: Hyperchylomicronemia
• E78.41: Elevated Lipoprotein(a)
• E78.49: Other hyperlipidemia
• E78.5: Hyperlipidemia, unspecified
• E78.6: Lipoprotein deficiency
• E78.70: Disorder of bile acid and cholesterol metabolism, unspecified