Transaminitis ICD-10-CM Codes

Read this short guide and learn about transaminitis ICD codes you can use. Learn about clinical and coding information here.

By Wynona Jugueta on Aug 8, 2025.

Fact Checked by Karina Jimenea.

Use Code

What ICD-10 codes are used for transaminitis?

While there are no explicit transaminitis ICD codes, you can still use the following ICD codes, under code range R00-R99: Symptoms, signs, and abnormal clinical and laboratory findings, note elsewhere classified, for clinical documentation:

R74.01: Elevation of levels of liver transaminase levels

This ICD-10 code, under R74: Abnormal serum enzyme levels, is meant to be used on a patient confirmed to have liver transaminase levels elevation. This is the specific ICD-10 code you're looking for. It's just phrased differently.

R89.0: Abnormal level of enzymes in specimens from other organs, systems and tissues

This ICD-10 code, under code range R83-R89: Abnormal findings on examination of other body fluids, substances, and tissues, without diagnosis, is meant to be used on a patient confirmed to have an abnormal level of enzymes in some other organ, system, and/or tissue. You can use this for transaminitis since transaminase is a liver enzyme. While this is another option, it's best to use Item 1.

Note that neither ICD-10 codes don't count as a principal diagnosis. Elevated transaminase levels are caused by something else, so the principal diagnosis should be for what's causing transaminase levels to rise.

Which transaminitis ICD codes are billable?

Both of these transaminitis-related ICD-10 codes are valid and considered as billable diagnosis codes despite not being valid as principal diagnoses.

Clinical information

Transaminitis is characterized by increased levels of certain enzymes, known as transaminases, in the liver. In particular, alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
It is commonly detected through blood tests and liver function tests, which measure the levels of liver enzymes and proteins in the blood.
Key causes of transaminitis include viral hepatitis, alcoholic liver disease, nonalcoholic fatty liver disease (NAFLD), and drug-induced liver injury.
Symptoms may be subtle or nonexistent in the early stages. In more severe cases, symptoms can include fatigue, loss of appetite, nausea, vomiting, and jaundice.
Management and treatment of transaminitis typically involve addressing the underlying condition contributing to the enzyme elevation. This could range from lifestyle changes, such as diet and exercise, to antiviral medications or cessation of a harmful medication.
Regular monitoring of liver enzyme levels is critical to assess the response to treatment and progression of the underlying liver disease.

Synonyms include

Elevated level of transaminase and lactic acid dehydrogenase
Aspartate transaminase level
Increased aspartate transaminase level
Elevation of levels of alanine transaminase (ALT)

Commonly asked questions

No. Perhaps it will be added in the future.

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Healthcare professionals will conduct blood tests, especially if the patient has symptoms or is at risk of liver disease.

Medicine, dietary changes that don’t include red meat and trans fats, exercising, and avoiding alcohol. For those with severe liver disease, a liver transplant might be recommended.

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