SIRS ICD-10-CM Codes

Which SIRS ICD code is billable?

Despite not being valid as principal diagnoses, these ICD-10 codes for SIRS are valid in general and billable.

Clinical information

Severe inflammatory response syndrome, or SIRS for short, is a life-threatening condition characterized by the body exhibiting an exaggerated defense mechanism to a stressor (e.g., underlying conditions, bacterial infections, surgery, ischemia, cancer, trauma, injury).

Because of this exaggerated response, severe inflammation will emerge throughout the body, which can cause organ dysfunction and damage. It's possible for organ dysfunction and damage caused by SIRS to be irreversible and kill a patient.

Healthcare professionals will diagnose a person with SIRS based on the following general symptoms and results of tests:

• If their body temperature is over 38°C or 100.4°F, or if it is below 36°C or 96.8°F
• If their heart rate is over 90 beats per minute
• If they have a respiratory rate of over 20 breaths per minute
• If they have a white blood cell count above 12,000 cells/mm³ or below 4,000 cells/mm³
• If a patient has two or more of the following, they will be diagnosed with SIRS.

If not treated, it can lead to acute respiratory failure, and if caused by infection (severe sepsis), it can lead to acute kidney failure.

Synonyms include:

• Non-infectious systemic inflammatory response syndrome
• Non-infectious systemic inflammatory response syndrome without acute organ failure
• Systemic inflammatory response syndrome
• Systemic inflammatory response syndrome without organ dysfunction
• Acute organ dysfunction due to systemic inflammatory response syndrome
• Sepsis syndrome
• Septic shock co-occurring with acute organ dysfunction due to anaerobic bacteria
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