SIRS ICD-10-CM Codes | 2023
Read this short guide to learn about SIRS ICD codes you can use!
Fact Checked by Nate Lacson.
What SIRS ICD-10 codes can I use?
If you’re looking for SIRS ICD codes, there are four ICD-10 codes that you can use. Here they are:
- R65.10 - Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
This ICD-10 code is meant to be used on patients confirmed to have Systemic Inflammatory Response Syndrome (SIRS). Their SIRS must not have an infectious origin, and it should not be accompanied by acute organ dysfunction.
- R65.11 - Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
This is the same as Item 1, but this time, the patient’s SIRS is accompanied by acute organ dysfunction.
- R65.20 - Severe sepsis without septic shock
While this doesn’t have SIRS in its name, it is related to SIRS. The first two items are for SIRS of a non-infectious origin. Sepsis is a severe form of SIRS that is related to infections.
- R65.21 - Severe sepsis with septic shock
This is the same as Item 3, but this time, the patient’s severe sepsis is accompanied by septic shock.
Please note that all four ICD-10 codes for SIRS are not valid as principal diagnoses. Underlying problems cause SIRS and Sepsis. Your principal diagnosis should be the cause, and these codes should support the principal diagnosis.
Are these SIRS ICD-10 codes billable?
Yes. Despite not being valid as principal diagnoses, these ICD-10 codes for SIRS are valid in general and billable.
Clinical information about SIRS:
Severe Inflammatory Response Syndrome, or SIRS for short, is a life-threatening condition characterized by the body exhibiting an exaggerated defense mechanism to a stressor (e.g., bacterial infections, surgery, ischemia, cancer).
Because of this exaggerated response, severe inflammations will emerge throughout the body, which can cause organ dysfunction and damage. It’s possible for organ dysfunction and damage caused by SIRS to be irreversible and kill a patient.
Healthcare professionals will diagnose a person with SIRS based on the following:
- If their body temperature is over 38°C or 100.4°F, or if it is below 36°C or 96.8°F
- If their heart rate is over 90 beats per minute
- If they have a respiratory rate of over 20 breaths per minute
- If they have a white blood cell count above 12,000 cells/mm³ or below 4,000 cells/mm³
- If a patient has two or more of the following, they will be diagnosed with SIRS.
Synonyms include:
- Non-infectious systemic inflammatory response syndrome
- Non-infectious systemic inflammatory response syndrome without acute organ failure
- Systemic inflammatory response syndrome
- Systemic inflammatory response syndrome without organ dysfunction
- Acute organ dysfunction due to systemic inflammatory response syndrome
- Sepsis syndrome
- Septic shock co-occurrent with acute organ dysfunction due to anaerobic bacteria
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Commonly asked questions
SIRS origins are non-infectious. If a bacterial infection is the cause, it is Sepsis. Think of Sepsis as the extreme version of SIRS.
They should observe if they or another person has the following:
- Chills and shaking
- Skin rashes, redness, and edema
- Severe tiredness
- Abnormal breathing
- Warm skin
- Sweaty skin
- If some of their bodily functions stop
- If they lose consciousness
Treatment will be based on dealing with the underlying cause, so it varies from patient to patient. Still, essential parts of treatment include the management of inflammations and ensuring the patient’s vital signs are stable.
