R74.01 – Elevation of levels of liver transaminase levels

R74.01 is an ICD-10-CM code for the elevation of levels of liver transaminase levels. Learn about its diagnosis, symptoms, billability, and answers to FAQs you may have.

By Karina Jimenea on Aug 8, 2025.

Fact Checked by Gale Alagos.

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R74.01 diagnosis code: Elevation of levels of liver transaminase levels

R74.01 is a billable ICD-10-CM code used for reimbursement for the diagnosis of elevation of levels of liver transaminase levels.
This ICD-10-CM code is used to diagnose the elevation of levels of liver transaminase levels in America. Internationally, this code may differ.
This code's umbrella category is “Symptoms, signs, and abnormal clinical and laboratory findings, not elsewhere classified” under “Abnormal findings on examination of blood, without diagnosis.”
R74.01 is only used when there's unknown or unavailable clinical information.
It's recommended that this code not be used as a principal diagnosis unless necessary as it is not definitive.

Is R74.01 billable?

Yes, R74.01 is billable for insurance reimbursement purposes.

Clinical information

Elevated liver transaminase levels mean that the patient has high levels of liver enzymes, namely alanine transaminase (ALT) and aspartate transaminase (AST), due to an injured or inflamed liver.
There are many causes of elevated ALT and AST levels. Among them are certain medications, metabolic syndrome, thyroid disorder, hepatitis, metabolic syndrome, and diseases like celiac, Wilson's, alcoholic liver, and nonalcoholic fatty liver. Aside from having these conditions, those who are at risk of having elevated levels are those with a personal or family history of liver disease, those taking certain medications, those with a history of alcohol abuse, and those who are exposed to hepatitis.
Those with mild liver transaminase levels elevation don't usually have symptoms and may be among the people whose liver state may be temporary. But those with severe elevations may exhibit symptoms like jaundice, fatigue, nausea, vomiting, diarrhea, abdominal pain, and changes in urine/stool color.
Various diagnostic methods may be employed to assess whether a patient has elevated levels. These can include conducting blood tests over a specific duration and requesting additional medical procedures such as ultrasounds, CT scans, MRIs, transient elastography, further blood tests, or even a liver biopsy.
Treatment will vary depending on the cause of the elevated levels.

Synonyms include:

ALT level raised
Aspartate aminotransferase serum level raised
Aspartate transminase level
Increased aspartate transaminase level
AST/SGOT level abnormal

Other ICD-10 codes commonly used for abnormal enzyme levels

R74: Abnormal serum enzyme levels
R74.0: Nonspecific elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
R74.8: Abnormal levels of other serum enzymes
R83.0: Abnormal level of enzymes in cerebrospinal fluid
R89.0: Abnormal level of enzymes in specimens from other organs, systems, and tissues

Commonly asked questions

Use R74.01 when a patient has elevated liver transaminase levels (ALT or AST) detected through blood tests, indicating potential liver dysfunction or damage. It is typically used when no more specific diagnosis explains the abnormal enzyme levels.

Yes, R74.01 is a billable ICD-10-CM code that can be used for reimbursement purposes when properly documented in a medical claim.

Diagnosis code R74.01 refers to elevated levels of liver transaminases, enzymes that indicate liver cell injury or disease. This finding may require further investigation to determine the underlying cause.

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