Lymphadenopathy ICD-10-CM Codes

Read this short guide to ICD-10 codes for lymphadenopathy. Learn more about the codes' billability, synonyms, and clinical descriptions.

By Patricia Buenaventura on Aug 8, 2025.

Fact Checked by Karina Jimenea.

Use Code

What ICD-10 Codes are used for Lymphadenopathy

Here's a list of the ICD-10 CM codes used for lymphadenopathy that's under the ICD-10-CM range R00-R99: Symptoms, signs and abnormal clinical laboratory findings, not elsewhere classified:

R59.0: Localized enlarged lymph nodes
R59.1: Generalized enlarged lymph nodes
R59.9: Enlarged lymph nodes, unspecified

For a more specific type of lymphadenopathy, healthcare providers can use the following ICD-10 codes:

L04.0: Acute lymphadenitis of face, head and neck
L04.1: Acute lymphadenitis of trunk
L04.2: Acute lymphadenitis of upper limb
L04.3: Acute lymphadenitis of lower limb
L04.8: Acute lymphadenitis of other sites
L04.9: Acute lymphadenitis, unspecified

Do note that, according to ICD-10-CM guidelines, you may only use this code when you or the referring physician has made a definitive, principal diagnosis.

Which lymphadenopathy ICD codes are billable?

Yes, the R59.0: Localized enlarged lymph node code is billable.
Yes, the R59.1: Generalized enlarged lymph node code is billable.
Yes, the R59.9: Enlarged lymph nodes, unspecified code is billable.
All of the more specific L04 codes are billable.

Clinical information

Lymphadenopathy is when a person's lymph nodes swell as a natural reaction to infection or illness. Swollen lymph nodes signify that the immune system is working to fight the disease.
Although it's more common for people to think that swollen lymph nodes are only located on the neck, they can also be found and get swollen around the jaw, chest, arms, abdomen, and leg area.
A patient has lymphadenopathy if their lymph nodes are larger, feel painful or tender when touched, are hard or rubbery in consistency, and feel connected. These symptoms may also be combined with the patient's illness or infection.
The causes of lymphadenopathy may vary depending on the location of the swollen nodes. Some common causes are upper respiratory infections, other conditions caused by bacteria/viruses, and STIs like human immunodeficiency virus (HIV) disease and syphilis.
Usually, swollen lymph nodes get better without treatment. However, if treatment is recommended, it depends on the lymph node's cause. The most common treatment is medication. However, if the lymph nodes are because of cancer, treatment may involve chemotherapy.

Synonyms include

Deep lymphadenopathy
Persistent generalized lymphadenopathy
Reactive lymphadenopathy
Superficial lymphadenopathy
Swelling or tenderness of lymphoreticular structure

Commonly asked questions

You can use a lymphadenopathy ICD code when determining that the patient has swollen lymph nodes and when you’ve made a definitive, principal diagnosis beforehand.

Yes, lymphadenopathy ICD-10-CM codes are billable.

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