Multiple Sclerosis ICD-10-CM Codes

Learn about the multiple sclerosis ICD-10 codes you can use through this guide.

By Matt Olivares on May 21, 2025.

Fact Checked by Karina Jimenea.

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Multiple Sclerosis ICD-10-CM Codes

What ICD-10 codes are used for multiple sclerosis?

Multiple sclerosis (MS) is a complex autoimmune disease in which the body's immune system mistakenly targets and damages its tissues. In the case of MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers, causing communication problems between the brain and the rest of the body. 

Over time, the disease can cause the nerves to deteriorate or become permanently damaged. The ICD-10-CM codes serve as a crucial tool for healthcare professionals, offering a detailed and systematic framework to classify, document, and manage the various stages and manifestations of MS.

The lone ICD code for multiple sclerosis is G35 - Multiple sclerosis. This foundational code indicates a diagnosis for MS. It's primarily employed when a patient's condition is diagnosed as MS, but without further specification regarding its type or stage. International versions of ICD codes for MS might differ in certain regions, so please double-check before using.

Is this multiple sclerosis ICD code billable?

Yes. This lone ICD-10-CM diagnosis code for multiple sclerosis is valid and billable. It can be used when making a diagnosis for reimbursement purposes.

Clinical information

Immune response

Multiple sclerosis (MS) is primarily a demyelinating disease. In this condition, the body's immune system mistakenly targets and damages the protective sheath (myelin) of nerve fibers in the central nervous system.

Etiology

The root cause of MS remains elusive. However, it's widely accepted that a blend of genetic predispositions coupled with environmental triggers, possibly including viral infections, may initiate the disease.

Diverse symptoms

MS manifests in a spectrum of symptoms, which can differ greatly among patients. Common indicators include:

  • Fatigue that isn't alleviated by rest.
  • Multiple sclerosis affects balance and can impact coordination and walking.
  • Numbness or weakness, often in one or more limbs.
  • Chronic pain or tingling sensations.
  • Visual disturbances, including blurred or double vision.

Treatment modalities

While a definitive cure for MS is yet to be discovered, several therapeutic interventions exist. These treatments aim to:

  • Alleviate acute symptoms.
  • Modulate the immune response to reduce future attacks.
  • Manage chronic symptoms to improve quality of life.

Importance of early intervention

Timely diagnosis and initiation of treatment can significantly influence the disease's trajectory. Early intervention often leads to slower progression, fewer complications, and an enhanced overall prognosis for the patient.

Forms of multiple sclerosis (MS)

  • Relapsing-remitting multiple sclerosis (RRMS): Representing the most prevalent form of MS, RRMS is characterized by episodes where new or exacerbated symptoms manifest, followed by periods of remission where these symptoms either improve significantly or vanish altogether.
  • Primary progressive multiple sclerosis (PPMS): PPMS stands apart from RRMS. From its onset, it showcases a continuous trajectory of symptom worsening, devoid of the distinct relapses or remissions that mark RRMS.
  • Secondary progressive multiple sclerosis (SPMS): Evolving from RRMS, SPMS is a phase where the disease's symptoms progress steadily. This progression can occur with or without the characteristic relapses or remissions of its predecessor, RRMS.
  • Progressive relapsing multiple sclerosis (PRMS): PRMS is a less common variant of MS. It merges the consistent progression observed in PPMS with the relapse episodes of RRMS. However, it doesn't offer periods of remission.

Synonyms include

  • MS
  • Chronic progressive multiple sclerosis
  • Disseminated sclerosis
  • Insular sclerosis
  • Sclerosis multiplex
  • Plaque sclerosis

Popular search terms for multiple sclerosis ICD-10 codes

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  • ICD-10 multiple sclerosis
  • Multiple sclerosis diagnosis codes
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Frequently asked questions

When do I use a multiple sclerosis ICD code?

When diagnosing a patient with MS or when documenting a patient's medical history with the disease.

What are the common treatments for multiple sclerosis diagnosis codes?

Treatments include disease-modifying therapies, physical therapy, medications for symptoms, and lifestyle changes.

What does a diagnosis code for multiple sclerosis do?

It provides a standardized way to document and categorize the type and stage of MS for clinical and billing purposes.

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