Macrocytic Anemia ICD-10-CM Codes | 2023

Explore ICD-10-CM codes for macrocytic anemia in 2023. Learn about common codes, billable statuses, and gain clinical insights in this comprehensive guide.

By Alex King on Aug 8, 2025.

Fact Checked by Ericka Pingol.

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What ICD-10 Codes are Used for Macrocytic Anemia

Macrocytic anemia is a type of anemia characterized by abnormally large red blood cells. Here are commonly used ICD-10-CM codes for macrocytic anemia, along with brief clinical descriptions:

D51.0 - Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with protein-bound vitamin B12: Used when macrocytic anemia is caused by selective vitamin B12 malabsorption with a specific protein-bound vitamin B12 deficiency.
D51.1 - Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with intrinsic factor deficiency: Applied when macrocytic anemia results from selective vitamin B12 malabsorption with intrinsic factor deficiency, affecting vitamin B12 absorption.
D51.2 - Transcobalamin II deficiency: Utilized for macrocytic anemia caused by a deficiency in transcobalamin II, a protein involved in vitamin B12 transport.
D51.3 - Other dietary vitamin B12 deficiency anemia: Used when macrocytic anemia is related to dietary vitamin B12 deficiency, not specifically due to malabsorption issues.
D51.8 - Other vitamin B12 deficiency anemias: Applied for other types of vitamin B12 deficiency-related macrocytic anemias not classified under the previous codes.
D51.9 - Vitamin B12 deficiency anemia, unspecified: Utilized when macrocytic anemia is due to vitamin B12 deficiency, but the specific cause is unspecified.

Which Macrocytic Anemia ICD Codes are Billable

The billable status of the mentioned ICD-10 codes for macrocytic anemia varies:

D51.0 - Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with protein-bound vitamin B12: Yes, billable. Medical expenses for this type of vitamin B12 deficiency-related macrocytic anemia can be claimed.
D51.1 - Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with intrinsic factor deficiency: Yes, billable. Costs associated with macrocytic anemia due to intrinsic factor deficiency can be reimbursed.
D51.2 - Transcobalamin II deficiency: Yes, billable. Medical expenses for macrocytic anemia resulting from transcobalamin II deficiency can be claimed.
D51.3 - Other dietary vitamin B12 deficiency anemia: Yes, billable. Expenses related to dietary vitamin B12 deficiency-related macrocytic anemia can be claimed.
D51.8 - Other vitamin B12 deficiency anemias: Yes, billable. Medical expenses for other vitamin B12 deficiency-related macrocytic anemias can be claimed.
D51.9 - Vitamin B12 deficiency anemia, unspecified: Yes, billable. Costs associated with unspecified vitamin B12 deficiency-related macrocytic anemia can be reimbursed.

Clinical Information

Macrocytic Anemia is a type of anemia characterized by abnormally large red blood cells (macrocytes).
It's typically diagnosed through a complete blood count (CBC) and peripheral blood smear, which reveals the enlarged red blood cells.
The most common causes of macrocytic anemia are deficiencies in vitamin B12 or folic acid, which can result from poor dietary intake, malabsorption, or other medical conditions.
Treatment often involves identifying and addressing the underlying cause of the vitamin deficiency, including dietary changes, oral supplements, or injections.
In cases where the anemia is severe or rapidly progressing, blood transfusions and additional medical interventions may be necessary.
Healthcare practitioners should emphasize the importance of treatment adherence and regular follow-up to monitor red blood cell counts and address the underlying cause.

Synonyms Include

Anemia with Large Red Blood Cells
ICD-10 Macrocytic Anemia
Megaloblastic Anemia
Vitamin B12 Deficiency Anemia
Folate Deficiency Anemia
Enlarged Red Blood Cells

Commonly asked questions

Macrocytic anemia can result from various factors, including vitamin B12 deficiency, folic acid deficiency, alcohol abuse, certain medications, and underlying health conditions.

Treatment depends on the underlying cause. It often involves addressing the deficiency, such as vitamin B12 or folic acid supplementation. In cases of intrinsic factor deficiency, vitamin B12 injections may be necessary.

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Neurological symptoms can include numbness or tingling in the hands and feet, difficulty walking, balance problems, and cognitive changes. These symptoms may be seen in severe vitamin B12 deficiency-related macrocytic anemia cases.

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