Sickle Cell Anemia ICD-10-CM Codes

Discover the correct ICD-10-CM codes for Sickle Cell Anemia in 2023. Explore standard codes, their billability, clinical data, synonymous terms, and more!

By Telita Montales on Aug 8, 2025.

Fact Checked by Nate Lacson.

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What ICD-10 Codes Are Used for Sickle Cell Anemia?

Sickle Cell Anemia, a severe disorder in which the body makes sickle-shaped red blood cells, has several specific ICD-10-CM codes:

D57.0 - Sickle-cell anemia with crisis: This code is used when a patient is experiencing a sickle-cell crisis characterized by pain episodes.
D57.1 - Sickle-cell anemia without crisis: This code is utilized when the patient has sickle-cell anemia but is not currently in crisis.
D57.2 - Sickle-cell/Hb-C disease with crisis: This code is for patients with a type of sickle cell disease that causes episodes of pain, known as crises.
D57.3 - Sickle-cell/Hb-C disease without crisis: This code is used for those diagnosed with sickle-cell but not currently in crisis.
D57.8 - Other sickle-cell disorders: This code covers other sickle-cell disorders that do not fit the above categories.

Which Sickle Cell Anemia ICD Codes Are Billable?

Each of these codes' billability depends on the specifics of the patient's condition and insurance policy:

D57.0 - Yes, it is billable, given that it denotes the diagnosis of sickle cell anemia with crisis.
D57.1 - Yes, this code is billable for diagnosing sickle cell anemia without crisis.
D57.2 - Yes, it's billable and refers to patients diagnosed with sickle cell/Hb-C disease with crisis.
D57.3 - Yes, this code is billable for patients with sickle cell/Hb-C disease without crisis.
D57.8 - Yes, this code is billable, referring to other sickle-cell disorders.

Clinical Information

Sickle cell anemia is a genetic disorder causing abnormal hemoglobin, leading to misshapen red blood cells.

Sickle cell anemia causes a shortage of red blood cells; these misshapen cells can block blood flow.
Symptoms include pain, frequent infections, delayed growth, and vision problems.
Treatment usually focuses on relieving symptoms and avoiding crises. It might consist of medications, blood transfusions, and in severe cases, bone marrow transplants.

Synonyms Include:

Hemoglobin S Disease
Sickle Cell Disorder
Drepanocytosis
Sickle Cell Disease
HbS Disease

Commonly asked questions

Several factors, including infection, dehydration, changes in temperature, stress, and high altitude, can trigger a sickle cell crisis. These factors can cause the sickle cells to block blood flow leading to pain crises.

Living with sickle cell anemia often involves managing symptoms and preventing crises. Regular check-ups, a healthy lifestyle, and adherence to treatment plans can enhance the quality of life and minimize complications.

No, individuals with sickle cell anemia cannot donate blood because their red blood cells are misshapen and could potentially cause complications for the receiver.

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