Neuroendocrine Tumor ICD-10-CM Codes | 2025

Learn about some of the common ICD-10 codes for neuroendocrine tumor diagnoses you can use through this guide.

By Matt Olivares on Aug 8, 2025.

What ICD-10 codes are used for neuroendocrine tumors

ICD-10 codes are essential for accurately documenting and coding various medical conditions, including neuroendocrine tumors (NETs). Neuroendocrine tumors are a group of rare cancers that arise from cells of the endocrine (hormone-producing) and nervous systems.

Here are the commonly used neuroendocrine tumors ICD-10 codes:

C25.0 - Malignant neoplasm of head of pancreas: This code is used for neuroendocrine tumors in the head of the pancreas. These tumors may cause symptoms related to the pancreas, such as abdominal pain, weight loss, and digestive issues.
C25.4 - Malignant neoplasm of endocrine pancreas: This code applies to neuroendocrine tumors specifically arising from the endocrine cells of the pancreas. These tumors can produce hormones, leading to various symptoms depending on the type of hormones released.
C25.9 - Malignant neoplasm of pancreas, unspecified: This code is used when the specific location within the pancreas is not specified. It is a general code for malignant neoplasms of the pancreas and is often used when the exact site of the tumor is not known.
C73 - Malignant neoplasm of the thyroid gland: This code is applicable when the neuroendocrine tumor is located in the thyroid gland. Neuroendocrine tumors of the thyroid can produce thyroid hormones, leading to symptoms like changes in metabolism and thyroid-related issues.
D44.9 - Neoplasm of uncertain behavior of unspecified endocrine gland: This code is applicable when there is a known neoplasm of uncertain behavior in an endocrine gland, but the gland isn't known/specified at the moment.

Accurate coding of neuroendocrine tumors using ICD-10 codes is crucial for proper medical recordkeeping, billing, and facilitating research on these rare and diverse malignancies.

Which neuroendocrine tumor ICD codes are billable?

All of the aforementioned ICD-10-CM codes are valid and billable.

In general, whether malignant or benign, ICD-10 codes for neuroendocrine tumors are billable as they are crucial for insurance claims, reimbursement, and maintaining accurate medical records.

However, it's essential to ensure that the specific guidelines and policies of the relevant healthcare payer or insurance provider use the codes. Always consult with coding experts, healthcare administrators, or billing professionals to ensure accurate and compliant coding practices.

Clinical information

Neuroendocrine tumors are rare cancers originating from endocrine and nervous system cells.
They can occur in various organs, including the pancreas, thyroid, lungs, and gastrointestinal tract.
Clinical manifestations vary based on the tumor's location and hormone production.
Common symptoms include abdominal pain, flushing, diarrhea, weight loss, and respiratory issues.
It is often associated with hormonal hypersecretion, leading to distinct clinical syndromes such as insulinoma (insulin overproduction) or gastrinoma (gastrin overproduction).
Arise from neuroendocrine cells and commonly affect the gastrointestinal tract and lungs.
It may produce serotonin, causing carcinoid syndrome characterized by flushing, diarrhea, and wheezing.
Imaging studies (CT, MRI, octreotide scans) help locate and characterize tumors.
Blood tests measuring specific hormones aid in diagnosis and determining the extent of hormonal activity.
Accurate coding is crucial for medical records, billing, and research.
Surgical resection is often the primary treatment, particularly for localized tumors.
Somatostatin analogs, chemotherapy, and targeted therapies are used based on tumor characteristics.
Prognosis varies widely depending on tumor type, grade, and stage.
Regular imaging and hormonal assessments are essential for monitoring disease progression and treatment efficacy.
Patient care involves collaboration among oncologists, endocrinologists, surgeons, and other specialists.
Individualized treatment plans consider the tumor's biology and impact on hormonal function.

Synonyms include

Carcinoid tumors
Islet cell tumors
Neuroendocrine neoplasms
Pancreatic endocrine tumors
Endocrine cell tumors
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs)
APUDomas (Amine Precursor Uptake and Decarboxylation tumors)
Malignant poorly differentiated neuroendocrine tumors
Malignant carcinoid tumor of the neuroendocrine system
Malignant neuroendocrine tumors
Tumor-associated endocrine syndrome
Multiple endocrine neoplasia
Benign carcinoid tumor of the neuroendocrine system
Neuroendocrine carcinoma

Popular search terms for neuroendocrine tumor ICD-10-CM codes

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Neuroendocrine tumor diagnosis codes
ICD-10 codes for neuroendocrine tumor

Commonly asked questions

Use a neuroendocrine tumor ICD code when documenting and coding a patient's diagnosis with a neuroendocrine tumor. These codes are essential for accurate medical recordkeeping.

All the aforementioned ones are, yes.

Common treatments for Neuroendocrine Tumor Diagnosis Codes include surgical resection, somatostatin analogs, chemotherapy, and targeted therapies. Treatment plans are individualized based on the tumor's characteristics.

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