HCPCS Code J8499: Prescription Drug, Oral, Non-Chemotherapeutic, NOS

J8499 should only be used when the oral non-chemotherapeutic drug being billed does not have an assigned HCPCS code.

In many cases, yes—especially for high-cost specialty medications. Payers may require clinical documentation before reimbursement.

Billing units vary by payer. Providers should report the exact quantity dispensed and follow payer-specific unit guidelines, ensuring NDC and dosage details are included on the claim.