Each Synvisc injection is 16 mg. Bill 16 units per injection. If a series of up to 3 injections is given, each injection is billed separately. The EJ modifier may be required for the second and third injections, depending on payer guidelines.

HCPCS Code J7325: Hyaluronan or Derivative, Synvisc or Synvisc-One, for Intra-Articular Injection, 1 mg
Bill and code J7325 accurately for Synvisc or Synvisc-One injections for knee osteoarthritis and intra-articular therapy.
Use Code
Frequently asked questions
Bill 48 units of J7325 for the one-time Synvisc-One dose.
For bilateral knee injections, indicate 2 injections (or double the units as appropriate per payer) and append the -50 modifier to the CPT code for the procedure (e.g., 20610). J7325 units are billed based on the mg administered per knee.
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