HCPCS Code J3304: Injection, Triamcinolone Acetonide, Preservative-Free, Extended‑Release Microsphere, 1 mg

HCPCS Code J3304: Injection, Triamcinolone Acetonide, Preservative-Free, Extended‑Release Microsphere, 1 mg

Learn billing, modifiers, and documentation for HCPCS code J3304: Injection, Triamcinolone Acetonide, Preservative-Free, Extended‑Release Microsphere, 1 mg.

Use Code
## **What is triamcinolone acetonide?** HCPCS code J3304 refers to Injection, Triamcinolone Acetonide, Preservative-Free, Extended‑Release Microsphere, 1 mg. Marketed under the brand name ZILRETTA®, this injectable corticosteroid is specially designed to treat pain associated with knee osteoarthritis by reducing inflammation and providing prolonged relief. The extended release microsphere formulation gradually releases triamcinolone into the joint, offering a sustained therapeutic effect over several weeks compared to standard injections. Being "preservative-free" means this formulation excludes additives commonly used to extend shelf-life, reducing potential irritation or allergic reactions. Other triamcinolone injections exist, including standard formulations containing preservatives that deliver shorter-term relief. J3304 ensures accurate billing per milligram administered to each patient, aligning reimbursement precisely with actual product usage.
## **J3304 documentation requirements** Accurate documentation is essential when billing for Injection, Triamcinolone Acetonide, Preservative-Free, Extended‑Release Microsphere, 1 mg. Complete medical records should include: ### **Diagnosis and indication** Record the precise diagnosis, such as symptomatic OA or specifically knee osteoarthritis, along with ICD-10 coding to clearly justify medical necessity. ### **Dose administered** Clearly document the exact dosage in milligrams of the extended-release microsphere formulation 1 mg administered to the patient. ### **Administration details** Record the route (major joint intra-articular injection), specific laterality (e.g., right knee), and method, including needle size and technique such as ultrasound guidance, if used. ### **Synovial fluid assessment** Document if synovial fluid aspiration was performed during the procedure and include relevant findings as part of medical necessity. ### **Medication identification** Include details such as lot number, expiration date, and National Drug Code (NDC) in the patient's records. ### **Treatment rationale and outcomes** Include a clear rationale for injection (for example, "previous inadequate response to NSAIDs"), and document outcomes such as improved pain or increased mobility to provide ongoing support for treatment.
## **J3304 billing requirements** For proper billing and reimbursement of Injection, Triamcinolone Acetonide, Preservative-Free, Extended‑Release Microsphere, 1 mg, follow these specific guidelines: ### **Accurate unit reporting** Bill 1 unit of HCPCS code J3304 precisely per 1 mg administered; for example, bill 32 units for a 32 mg dose. ### **CPT code usage** Pair HCPCS J3304 with CPT code 20610 (arthrocentesis or injection, major joint) for the procedure itself. ### **Laterality modifiers** Include RT (right) or LT (left) modifiers to identify joint laterality clearly, such as injections performed specifically in the right knee. ### **Drug wastage modifiers** Include JW modifier if part of the drug from the single-dose vial was discarded, or JZ modifier if no wastage occurred, as mandated by CMS guidelines. ### **NDC and payer compliance** Always provide the NDC and verify payer-specific coverage policies for the extended-release microsphere formulation 1 mg, particularly for Medicare and Medicaid services, to ensure claims are accurately covered.
## **J3304 applicable modifiers** Applicable modifiers for billing HCPCS code J3304 include: 1. **JW**: Indicates a portion of the drug was discarded. 1. **JZ**: Confirms no drug wastage occurred (required by CMS from July 1, 2023). 1. **RT/LT**: Identify injection location laterality (right or left knee). 1. **99**: Used if multiple modifiers are required per payer-specific instructions. Providers must comply with CMS rules and payer guidelines for modifier usage.
## **Other relevant codes** Providers frequently report related CPT/HCPCS codes alongside HCPCS code J3304 for joint injection procedures or similar injectable corticosteroids: - **20610**: Arthrocentesis or injection, aspiration and/or injection; major joint (e.g., knee, shoulder). - **20611**: Arthrocentesis or injection, aspiration and/or injection; major joint with ultrasound guidance. - **J3300**: Injection, Triamcinolone Acetonide, standard formulation, 1 mg; shorter-duration relief for osteoarthritis. - **J7325**: Hyaluronan or derivative injection, 1 mg, used to manage symptomatic OA. - **20605**: Arthrocentesis or injection, intermediate joint or bursa, e.g., subacromial bursa.

Frequently asked questions

Yes, ZILRETTA is a type of corticosteroid injection specifically formulated as an extended-release microsphere formulation to provide longer-lasting relief from knee osteoarthritis pain compared to standard cortisone injections.

The appropriate CPT code to bill for ZILRETTA injections into a knee (major joint) is 20610, or 20611 if administered under ultrasound guidance.

Medicare typically covers ZILRETTA injections when medically necessary and administered no more frequently than every three months per affected joint, provided medical documentation clearly supports the clinical need.

EHR and practice management software

Get started for free

*No credit card required

Free

$0/usd

Unlimited clients

Telehealth

1GB of storage

Client portal text

Automated billing and online payments