HCPCS Code J1559: Injection, Immune Globulin (Hizentra), 100 mg

The code description for J1559 is “Injection, immune globulin (Hizentra), 100 mg.” It applies when billing for Hizentra, a subcutaneous immune globulin therapy.

Hizentra is delivered through a subcutaneous infusion site, typically in the abdomen, thigh, upper arm, or hip. Multiple sites may be used at once depending on the prescribed dose and patient tolerance.

In most cases, J1559 does not require a modifier code. However, some payers may request modifiers if multiple infusions or an additional pump setup is used. Always check payer-specific guidelines.

Hizentra is commonly prescribed for patients with predominantly antibody defects (immune disorders where antibody production is impaired). These lead to recurrent infections and require ongoing immunoglobulin replacement to maintain immune defense.