HCPCS Code J0561: Injection, Penicillin G Benzathine, 100,000 units

HCPCS Code J0561 is used to report the injection of Penicillin G Benzathine, 100,000 units. Each billing unit represents 100,000 units of the drug, so a typical 1.2 million-unit dose would be billed as 12 units of J0561. It is commonly administered for the treatment of bacterial infections such as streptococcal pharyngitis, syphilis, and rheumatic fever prophylaxis.

When billing J0561, report the total number of units administered based on the patient’s dosage. Be sure to include an administration code (such as CPT 96372) to capture the injection service itself. Note that CPT 96372 is billed once per encounter, regardless of the number of J0561 units administered.

Yes, but only when clinically appropriate and supported by documentation. For example, J0558 (Penicillin G benzathine and penicillin G procaine) and J0570 (Penicillin G procaine) may apply in different treatment scenarios. Always follow payer-specific bundling rules.

Some Medicaid and commercial plans may require prior authorization for Penicillin G Benzathine injections, especially for higher doses or repeated administrations. Providers should verify payer-specific prior authorization requirements before administration to reduce claim denials.