CPT code 17000: Destruction of premalignant lesion, first lesion
Learn how the requirements and guidelines of using CPT 17000, a code for the destruction of premalignant lesions, first lesion.

What is the CPT code 17000?
CPT code 17000 is used to destroy the first actinic keratosis (AK) or other premalignant skin lesions through cryosurgery, laser, chemical application, or electrosurgery. The procedure is generally performed in outpatient dermatologic settings and is a cornerstone of skin cancer prevention.
Actinic keratoses are rough, scaly patches caused by cumulative sun damage and are considered precancerous due to their potential to progress to squamous cell carcinoma.
This code applies to the first lesion only; additional lesions are separately coded and not bundled into 17000. If multiple lesions are treated, CPT 17003 and 17004 may apply depending on the total number.
CPT code 17000 documentation requirements
Following proper coding practices is crucial for a smoother and more accurate billing process. One of the well-known practices is to include the following information in the patient's medical records:
- Anatomical location and description of the lesion(s)
- Clinical diagnosis (e.g., actinic keratosis)
- Method of lesion removal (e.g., cryotherapy with liquid nitrogen)
- Date and number of lesions treated
- Proof of medical necessity and consent for treatment
Do note that photographs may be helpful but are not required. Each lesion must be clearly recorded, especially when multiple codes are submitted.
CPT code 17000 billing guidelines
To streamline the billing process and subsequently improve revenue cycle management, healthcare professionals must comply with the following billing and coding guidelines:
- Medical necessity is provided.
- Specific guidelines and coverage policies have been checked or reviewed, as some payers have specific requirements for documenting medical necessity.
- Only the first lesion treated is used for the code. Additional lessons are billed using other CPT codes, like CPT 17003 and 17004.
- Use modifiers if necessary for more accurate billing. For example, modifier 59 may be used for independent or distinct procedural services performed on the same day, or modifier 25 may be used if a significant, separately identifiable evaluation and management (E/M) service is performed on the same day as the destruction.
- Follow the National Correct Coding Initiative (NCCI) guidelines to ensure accurate billing and prevent unbundling or incorrect code combinations. This helps reduce claim denials, avoid audits, and ensure timely reimbursement from payers.
Commonly asked questions
No, 17000 is for premalignant lesions only.
No, a clinical diagnosis is sufficient if consistent with actinic keratosis and documented.
CPT 17000 is for the first lesion, and 17003 is reported per additional lesion up to 14. Use 17004 if treating 15 or more.