ESBL ICD-10-CM Codes | 2025

Read this short guide to learn about ESBL ICD codes you can use!

By Matt Olivares on Jun 01, 2025.

Fact Checked by Gale Alagos.

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ESBL ICD-10-CM Codes | 2025

What ESBL ICD-10 codes can I use?

If you're looking for ESBL ICD codes, please note that there is only one ICD-10 code that specifically mentions ESBL in its name: Z16.12 - Extended spectrum beta lactamase (ESBL) resistance.

This ICD-10 code is meant to be used on a patient confirmed to have been infected with bacteria that produce extended spectrum beta lactamase. ESBL can make the bacteria that produce it more resistant to antibiotics.

Use this ICD-10 code if your patient has bacteria that can fight off the effects of antibiotics due to ESBL.

One thing to note about this code is that it's considered unacceptable as a principal diagnosis since it's meant to explain that there is resistance to antibiotics due to bacteria with ESBL.

The main ICD-10 code you need to use should be for designating a bacterial infection. The closest ICD-10 you can use for that is A49.8 - Other bacterial infections of unspecified site, because there are no specific ICD-10 codes that specify ESBL bacterial infection.

Are these ESBL ICD-10 codes billable?

Yes. Both these ICD-10 codes for ESBL are valid and billable.

Clinical information about ESBL:

Extended spectrum beta lactamase, or ESBL for short, is an enzyme produced by Gram-negative bacteria like Escherichia coli and Klebsiella pneumoniae. They aid bacteria by fortifying their resistance to certain antibiotics made specifically to destroy them. These antibiotics include carbapenems and penicillins, to mention a few.

ESBLs are troublesome for patients and healthcare professionals because they make treatment processes difficult by rendering certain antibiotics ineffective. This might limit the treatment options for patients. This forces healthcare professionals to consider alternative options to combat the bacteria.

This is potentially dangerous because if more and more bacteria become resistant to antibiotics, it will be harder to treat bacterial infections. It can even lead to problems like urinary tract infections and lung problems.

Synonyms include

  • Infection caused by ESBL Klebsiella oxytoca
  • Infection caused by ESBL Proteus mirabilis
  • Infection due to ESBL bacteria
  • Infection due to ESBL Escherichia coli
  • Extended spectrum beta lactamase
  • Extended spectrum beta lactamase resistance
  • ESBL aiding methicillin resistant staphylococcus aureus infections
  • Resistant bacterial agents
  • Bacteria remaining despite multiple antibiotics have been administered
  • Infectious agent with antibiotic resistance
  • Local infections with ESBL bacteria
  • Antimicrobial drugs not as effective due to ESBL
  • Escherichia coli e
  • Beta lactam antibiotics
  • ESBL bacteria as the cause of diseases classified elsewhere

Popular search terms for ESBL ICD-10-CM codes

  • ESBL ICD 10
  • ICD-10 codes for ESBL
  • ESBL UTI ICD 10
  • ICD-10 ESBL
  • ESBL e coli ICD 10
  • ESBL diagnosis codes

Frequently asked questions

Are ESBLs dangerous?

Yes. Besides making bacteria resistant to antibiotics, they can prolong a person’s illness, and prolonged illnesses can lead to unwanted complications.

Can ESBL-producing bacteria transfer from person to person?

Yes. These bacteria are often found in healthcare facilities, so professionals must disinfect their workplaces and isolate patients to prevent the spread of these bacteria.

How can healthcare professionals detect bacteria that produce ESBLs?

They will conduct special tests, such as Vitek ESBL tests and MicroScan Panels, to determine if the bacterial sample collected can produce ESBLs.

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