F06.30 – Mood disorder due to known physiological condition, unspecified

A mood disorder due to a known physiological condition occurs when a medical illness, injury, or physiological factor directly causes significant mood disturbances. These mood changes can include depression, mania, or mood swings and are not attributable to primary psychiatric disorders or substance use. Proper diagnosis requires identifying the underlying medical condition responsible for the symptoms.

A major affective disorder refers to a category of psychiatric conditions that significantly impact mood, including major depressive disorder, bipolar disorder, and schizoaffective disorder. These disorders are characterized by persistent and severe emotional disturbances, such as prolonged depression or episodes of mania, that interfere with daily life. Treatment typically involves medication, psychotherapy, or a combination of both.

F06.31 is the ICD-10-CM code for mood disorder due to a known physiological condition with depressive features. As a primary diagnosis, it indicates that a patient’s depressive symptoms—such as low mood, fatigue, or loss of interest—are directly caused by an underlying medical condition rather than a primary psychiatric disorder. Management focuses on treating both the mood symptoms and the underlying physiological cause.