HCPCS code S9500 is for home infusion therapy involving antibiotic, antiviral, or antifungal therapy provided once every 24 hours. It covers administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment, with drugs and nursing visits billed separately. This code is used per diem for home therapy services and indicates a high level of service complexity.

HCPCS Code S9500: Home Infusion Therapy, Antibiotic, Antiviral, or Antifungal Therapy; Once Every 24 Hours
If you're getting a lot of S9500 denials, read our guide, complete with billing and documentation tips. Get paid for every claim.
Frequently asked questions
Medicare does not cover HCPCS code S9500. However, since January 1, 2021, Medicare pays for Home Infusion Therapy (HIT) professional services using Medicare-specific G-codes (e.g., G0068–G0070). Under Medicare, S9500 is not billable; instead, bill the HIT G-codes for the professional component and bill the drug and most supplies/equipment separately under their own codes.
HCPCS code S9500 is for home infusion therapy antibiotic, antiviral, or antifungal therapy provided once every 24 hours, including all necessary supplies and services. S9501 is similar but covers therapy administered once every 12 hours, reflecting a higher frequency of service.
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