HCPCS Code J3490: Unclassified Drugs

Learn about the HCPCS code J3490, which is meant to designate the use of unclassified drugs, through this short guide.

Frequently asked questions

Use J3490 only when no specific HCPCS code exists for the drug. Do not use J3490 if a defined code exists.

Yes—some payers, including Medicaid agencies, require prior authorization (PA) for certain drugs billed with J3490, or may mark them as not covered (NC). Always consult local payer drug directives or authorization lists before submitting.

Risks vary depending on the drug. Allergic reactions, injection site reactions, systemic reactions, and organ-specific side effects are some of the risks. It's best to monitor the patient for a bit after administering the drug to them.