HCPCS Code J2506: Injection, Pegfilgrastim, Excludes Biosimilar, 0.5 mg

J2505 describes pegfilgrastim 6 mg per dose, while J2506 is billed per 0.5 mg and is the specific code for originator pegfilgrastim that excludes biosimilar products. Many payers prefer J2506 for unit-based billing precision; use biosimilar Q-codes when a biosimilar is administered and follow payer policy for code selection.

Neulasta (originator pegfilgrastim) is billed with J2506 per 0.5 mg; some payers may still accept J2505 for a single 6 mg dose, so verify plan rules. Report the administration separately—96372 for a standard subcutaneous injection or 96377 when applying the on-body injector for a timed subcutaneous injection.

Use 96372 for the intramuscular administration of Invega Sustenna (paliperidone palmitate). Bill the drug supply with the HCPCS product code J2426 (injection, paliperidone palmitate, extended-release, per 1 mg) with units matching the dose.