HCPCS Code A4221: Supplies for Maintenance of Non-Insulin Drug Infusion Catheter, Per Week

HCPCS code A4221 is for supplies used in the maintenance of a non-insulin drug infusion catheter, billed per week, listing drugs separately. It includes dressings, flush solutions, and related infusion supplies required for catheter site upkeep. This code is distinct from insulin pump supplies and linked to external infusion pumps.

Medicare covers HCPCS code A4221 under the Durable Medical Equipment (DME) benefit when used with a covered non-insulin external infusion pump (e.g., E0779, E0780). Coverage requires compliance with medical necessity and documentation rules set by Medicare Administrative Contractors (MACs). This code is payable by DME MACs as part of infusion supply coverage.

An external insulin infusion pump is a battery-operated, programmable device worn externally that delivers continuous, controlled insulin infusion subcutaneously via a catheter. It provides basal insulin and bolus doses regulated by the user to manage blood glucose levels in diabetes treatment.