No, CPT 99381 is for preventive medicine services, not illness. If a separate, significant problem-oriented E/M service is provided on the same day, it may be billed with Modifier -25 appended to the E/M code, not to 99381.

CPT Code 99381: Initial Preventive Medicine E/M, Infant (Under 1 Year)
Learn more about CPT code 99381 and how it relates to pediatric preventive care to optimize coding and billing processes.
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Frequently asked questions
CPT 99381 is reimbursed once per lifetime, as it applies to the initial preventive medicine visit for new patients under 1 year of age.
Yes, basic developmental screenings are included in CPT 99381. However, use of standardized tools (e.g., 96110) for more detailed assessments may be reported separately if medically indicated and documented.
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