No, billing 80050 and 80053 together is considered unbundling, as CPT 80050 already includes 80053 as part of the panel. If all components (CMP, CBC with differential, and TSH) are performed, report 80050 only, per organ or disease-oriented panel rules and AMA coding guidelines.

CPT Code 80050: General Health Panel
Understand CPT code 80050 for general health panels, including documentation, billing rules, and medical decision-making guidelines.
Frequently asked questions
No, CPT 80050 does not include lipid panels or hemoglobin A1c. These are separate clinical laboratory procedures and must be ordered and billed individually. If reviewed, they may also contribute to medical decision making under office and outpatient evaluation guidelines.
Yes, a valid physician order is required for all lab panels, including CPT 80050. The order must include a clinical indication to meet payer coverage criteria and support the review of each unique test and review under MDM guidelines for medical decision making.
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