Splenomegaly

Discover the updated ICD-10-CM codes for splenomegaly in 2025. Ensure accurate coding and billing for this medical condition.

By Wynona Jugueta on Aug 8, 2025.

Fact Checked by Karina Jimenea.

Use Code

What ICD-10 codes are used for splenomegaly?

Splenomegaly is characterized by an enlarged spleen, often indicative of an underlying medical condition. Proper diagnosis and coding are essential for accurate medical records and effective treatment. Here are some commonly used ICD-10 codes for splenomegaly, along with their clinical descriptions:

R16.1: Splenomegaly, not elsewhere classified: The code R16.1 refers to splenomegaly (enlarged spleen) that is not attributed to a specific cause or classified under another diagnosis.

D69.59: Other secondary thrombocytopenia: This code is used when splenomegaly is associated with decreased platelet count due to a secondary cause. It indicates a condition where the spleen plays a role in the destruction or sequestration of platelets.

D59.4: Other non-autoimmune hemolytic anemias: This code is used when splenomegaly is associated with the accelerated destruction of red blood cells due to a non-autoimmune cause. It denotes a condition where the spleen contributes to the breakdown of red blood cells.

D47.3: Essential (hemorrhagic) thrombocythemia: This code refers to essential thrombocythemia, a chronic blood disorder marked by excessive platelet production, which can lead to complications such as blood clots and may cause splenomegaly due to the spleen working harder to filter abnormal blood cells.

D73.1: Felty's syndrome: Felty's syndrome is a rare complication of rheumatoid arthritis characterized by an enlarged spleen, low white blood cell count, and increased risk of infections.

D73.81: Neutropenic splenomegaly: The code refers to neutropenic splenomegaly, a condition where an enlarged spleen is associated with neutropenia, meaning abnormally low levels of neutrophils, a type of white blood cell important for fighting infection.

Which splenomegaly ICD codes are billable?

R16.1: Splenomegaly, not elsewhere classified: Yes
D69.59: Other secondary thrombocytopenia: Yes
D59.4: Other non-autoimmune hemolytic anemias: Yes
D47.3: Essential (hemorrhagic) thrombocythemia: Yes
D73.1: Felty's syndrome: Yes
D73.81: Neutropenic splenomegaly: Yes

Clinical information

Splenomegaly refers to the abnormal enlargement of the spleen, a vital organ located in the upper left abdomen. It filters blood, supports immunity, and stores blood cells.
Various underlying medical conditions or factors, including infections, immunity disorders, unspecified diseases, other specified diseases, transient neonatal neutropenia, blood disorders, and certain cancers, can cause splenomegaly. It may also be seen in splenomegaly not elsewhere classified or splenomegaly NOS cases, which are often recorded when no specific classification applies.
The clinical presentation of splenomegaly may vary depending on the underlying cause and the severity of enlargement. Common symptoms include abdominal pain or discomfort, a feeling of fullness or early satiety, fatigue, easy bruising or bleeding, frequent infections, or difficulty taking a deep breath due to pressure on adjacent organs.
Blood tests are often performed to identify related conditions, including anemia, infection, or immune abnormalities. Physical examination may reveal a palpable, enlarged spleen during abdominal assessment.
Diagnostic imaging such as ultrasound, CT scan, or MRI can confirm the presence and measure the extent of splenomegaly. These evaluations also help detect other diseases that may be contributing to spleen enlargement.
Treatment of splenomegaly focuses on managing symptoms, preventing complications, and addressing the underlying condition. In some cases, such as with persistent transient neonatal neutropenia or complications due to other diseases, surgical spleen removal (splenectomy) may be necessary.
Splenomegaly requires ongoing monitoring to prevent serious complications such as splenic rupture, anemia, or immune system dysfunction. Accurate documentation using appropriate ICD-10 codes—including classifications for other specified diseases or unspecified diseases—supports effective diagnosis, treatment planning, and research.

Synonyms include:

Enlarged spleen
Splenic enlargement
Splenomegaly
Megalosplenia
Hypersplenia

Commonly asked questions

ICD codes for splenomegaly are used to document and classify the condition based on clinical findings and diagnostic results. These codes help ensure accurate billing, treatment planning, and medical recordkeeping.

Yes, multiple ICD codes can be used when splenomegaly is associated with other conditions or when further specificity is needed. For example, you may code both the underlying cause and the presence of splenomegaly NOS or splenomegaly not elsewhere classified.

Yes, ICD-10 includes specific codes that correspond to various causes of splenomegaly. Proper coding depends on identifying the root cause through clinical evaluation and blood tests.

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