Pancytopenia ICD-10-CM Codes

Dive into the guide on Pancytopenia ICD-10-CM codes. Learn about the specific codes, clinical descriptions, and billing implications.

By Patricia Buenaventura on Aug 8, 2025.

Fact Checked by Karina Jimenea.

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What ICD-10 codes are used for pancytopenia?

Pancytopenia is a medical condition characterized by a reduction in all types of blood cells.

Here are the commonly used pancytopenia ICD codes, which can be found within the code range D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, specifically under D61: Other aplastic anemias and other bone marrow failure syndromes:

D61.810: Antineoplastic chemotherapy-induced pancytopenia
D61.811: Other drug-induced pancytopenia
D61.818: Other pancytopenia

Do note that these codes, or at least the codes under D61.81: Pancytopenia, excludes pancytopenia due to conditions or disorders like aplastic anemia, bone marrow infiltration, hairy cell leukemia, congenital (pure) red cell aplasia, and leukoerythroblastic anemia.

To add, it's possible that a patient may have pancytopenia that falls under D61.8 (Other specified aplastic anemias and other bone marrow failure syndromes) but also has pancytopenia due to myelodysplastic syndromes. If that's the case, both codes must be used by the healthcare provider.

Which pancytopenia ICD codes are billable?

Determining which Pancytopenia ICD codes are billable is essential for healthcare providers. All of the aforementioned codes above are valid and billable.

Clinical information

Pancytopenia is a severe medical condition that requires comprehensive evaluation and treatment. Here's what you need to know:

Symptoms often include fatigue, weakness, frequent infections, and easy bruising or bleeding.
Bone marrow failure syndromes/disorders, human immunodeficiency virus disease, certain medications, or systemic diseases like lupus can cause the condition.
Diagnosis involves blood tests, bone marrow biopsy, and sometimes genetic testing.
Treatment options include medications that stimulate the blood cell production in the bone marrow, blood transfusions, and bone marrow transplantation
Early diagnosis and treatment are crucial to manage symptoms and treat underlying causes.

Synonyms include

Bone marrow failure
Hematopoietic failure
Aplastic anemia
Leukopenia
Thrombocytopenia

Commonly asked questions

Common triggers for pancytopenia include chemotherapy, certain medications like antiepileptics, viral infections like HIV, and autoimmune diseases like lupus.

The severity of pancytopenia is usually determined through a complete blood count (CBC) and bone marrow biopsy. These tests help assess the levels of red blood cells, white blood cells, and platelets.

Untreated pancytopenia can lead to severe complications such as life-threatening infections, uncontrollable bleeding, and increased susceptibility to other diseases due to a weakened immune system. Early intervention is crucial for a better prognosis.

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