Leukopenia ICD-10-CM Codes

Explore ICD-10 codes for leukopenia, including D72.819 and D70.1. Learn about coding, diagnosis, billing details, causes, and treatment options.

By Wynona Jugueta on Aug 8, 2025.

Fact Checked by Karina Jimenea.

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What ICD-10 codes are used for Leukopenia?

Leukopenia refers to a decrease in the number of white blood cells (WBCs), which play a crucial role in the body's immune defense. This condition can lead to a higher risk of infections and often occurs alongside systemic symptoms syndrome or other disorders involving the blood and immune system.

Healthcare providers rely on specific ICD-10 codes to accurately diagnose, document, and bill for leukopenia and its variants. These codes fall under the category of diseases classified as diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.

D72.819: Decreased white blood cell count, unspecified

This code pertains to one of the most frequently used leukopenia ICD codes. It is applied when the underlying cause of leukopenia remains unspecified, aligning with decreased leukocytes or unspecified leukopenia type.

D72.818: Other decreased white blood cell count

This code applies when leukopenia is triggered by other specified disorders, including medication-induced cases, autoimmune diseases, and bone marrow conditions. It helps healthcare providers document blood disorders not otherwise classified.

Which leukopenia ICD-10 codes are billable:

D72.819: Yes
D72.818: Yes

These billable codes are essential for proper documentation of disorders involving blood and immune function.

Clinical information

Leukopenia involves a reduction in white blood cells, including basophils, lymphocytes, and other WBC subtypes, reflected in blood cell count unspecified results. This condition can stem from blood-forming organ dysfunction, immunity disorders, or other specified diseases of the blood.
Leukopenia may result from infections (bacterial, viral, fungal, parasitic), chemotherapy, corticosteroids, autoimmune conditions (like lupus or rheumatoid arthritis), radiation exposure, malnutrition, pregnancy, or other disorders classified under blood and immune system diseases.
Common systemic symptoms syndrome features may include fever, chills, fatigue, mouth sores, sore throat, frequent infections, easy bruising, or bleeding.
Diagnosis typically involves a complete blood count (CBC) and further evaluation of functional disorders of white blood cells. Testing may also reveal abnormalities like white blood cells basophilia or decreased leukocytes.
Treatment depends on the cause and can involve managing infections, modifying medications, administering white blood cell transfusions, or treating other specified disorders and diseases classified under immune mechanism issues.
Healthcare providers may recommend vaccines, healthy nutrition, minimizing exposure to infection risks, and careful monitoring of blood disorders to prevent complications.

Synonyms include:

Decreased white blood cell count
Low white blood cell count

Commonly asked questions

A leukopenia ICD code should be used when a patient is diagnosed with a low white blood cell count, confirmed through diagnostic testing like a complete blood count (CBC). These codes help healthcare providers accurately document and bill for conditions involving decreased leukocytes or other blood cell abnormalities.

Treatment for leukopenia typically depends on the underlying cause and may include managing infections, adjusting medications, or administering white blood cell growth factors. In severe cases, treatments like white blood cell transfusions or bone marrow support therapies may be recommended.

A diagnosis code for leukopenia indicates that the patient has a medically confirmed low white blood cell count, which may compromise immune function and increase infection risk. The code helps classify the specific type or cause of leukopenia, guiding appropriate care and treatment plans.

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