Hepatic Encephalopathy ICD-10-CM Codes

Hepatic Encephalopathy ICD-10-CM Codes

Learn about ICD-10-CM codes for hepatic encephalopathy, related codes, billing info, diagnosis, and treatment options.

By Wynona Jugueta on Jul 16, 2025.

Fact Checked by Karina Jimenea.

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What are Hepatic Encephalopathy ICD-10-CM Codes?

Hepatic encephalopathy is a serious neurological complication associated with liver disease. The primary ICD-10-CM code used to document this condition is:

  • K76.82 – Hepatic encephalopathy: This is the specific international classification code for hepatic encephalopathy, whether the condition is acute, chronic, or subacute. It is used in both internal medicine and hepatology settings to capture the diagnostic accuracy and support medical billing.

While K76.82 remains the central code, related hepatic conditions may also be required for complete medical coding:

  • K72.90 – Hepatic failure, unspecified without coma
  • K72.91 – Hepatic failure, unspecified with coma
  • K72.00 – Acute and subacute hepatic failure without coma
  • K72.01 – Acute and subacute hepatic failure with coma
  • K72.10 – Chronic hepatic failure without coma
  • K72.11 – Chronic hepatic failure with coma

Additionally, in cases involving toxic metabolic encephalopathy, you may use:

  • G92.8 – Other toxic encephalopathy: A code used to describe brain dysfunction caused by exposure to toxic substances, excluding those covered by more specific codes. It can result in symptoms like confusion, memory problems, or altered mental status due to toxins such as chemicals, drugs, or environmental exposures

Which Hepatic Encephalopathy ICD-10-CM Codes are billable?

All codes listed above are valid and billable ICD-10-CM codes. They can be used in both inpatient and outpatient settings for documentation and reimbursement purposes. These codes ensure diagnostic performance aligns with coding compliance and payer requirements.

Clinical information

Hepatic encephalopathy (HE) is a neuropsychiatric complication of liver failure, most commonly seen in patients with cirrhosis, chronic hepatic failure, or subacute hepatic failure. This condition results from the liver’s reduced capacity to detoxify substances in the blood, leading to a buildup of neurotoxins that impair brain function.

Common clinical features

  • Confusion, personality changes, irritability
  • Sleep disturbances and altered mental status
  • Asterixis ("flapping tremor")
  • In severe cases, hepatic coma or hepatic failure with coma

HE may be triggered by infections, GI bleeding, electrolyte imbalances, or medications, especially in patients with alcoholic hepatic failure or toxic encephalopathy.

Management and treatment

  • Correction of precipitating factors
  • Lactulose to reduce ammonia absorption
  • Rifaximin for long-term toxin control
  • Nutritional therapy, including low-protein diets in selected cases

Prognostic considerations

Prognosis depends on:

  • Severity of underlying liver disease
  • Frequency and duration of HE episodes
  • Treatment adherence and comorbidities
  • Risk of recurrence, particularly in identified patients with static encephalopathy

Synonyms include

  • Hepatic coma
  • Hepatic coma due to hepatitis
  • Hepatic encephalopathy
  • Hepatic encephalopathy in fulminant hepatic failure

Related ICDs

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