Factor V Leiden Mutation ICD-10-CM Codes

Navigate the ICD-10-CM codes for the genetic condition Factor V Leiden Mutation in 2023—essential coding guide for thrombophilia disorders.

By Olivia Sayson on Aug 8, 2025.

Fact Checked by Nate Lacson.

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What ICD-10 Codes are Used for Factor V Leiden Mutation

Factor V Leiden mutation is a genetic disorder that makes blood clotting (thrombophilia) more likely, increasing the risk for deep vein thrombosis and pulmonary embolism. The ICD-10-CM system has designated codes to classify this genetic predisposition.

Here's the primary ICD-10-CM code for Factor V Leiden Mutation:

D68.59: Other primary thrombophilia

Clinical Description: This code can denote inherited thrombophilia conditions like the Factor V Leiden mutation.

Which Factor V Leiden Mutation ICD Codes are Billable:

D68.59: Yes

Clinical Information

Factor V Leiden mutation is the most common hereditary hypercoagulability disorder among individuals of European descent.
The mutation results in a variant of human factor V, making it resistant to cleavage and promoting clotting.
Individuals with this mutation have a higher risk of developing abnormal blood clots in veins.
Symptoms aren't always present until a clot forms; signs then depend on the clot's location.
Treatment may include anticoagulant medications, especially if an individual has a history of blood clots.
Not everyone with the mutation will develop clots, but they are at a higher risk, especially in the presence of other predisposing factors.

Synonyms Include

Hereditary resistance to activated protein C
APC resistance
Factor V mutation
Genetic thrombophilia

Commonly asked questions

A Factor V Leiden Mutation ICD-10-CM code should be applied in medical documentation when diagnosing or managing a patient with this specific inherited genetic predisposition to thrombophilia.

The mutation is diagnosed through a blood test, often initiated because of a personal or family history of blood clots or when other signs of increased clotting risks are identified.

A diagnosis code for Factor V Leiden Mutation provides a standardized way of indicating that a patient has been identified with this specific genetic condition predisposing them to abnormal blood clotting. It aids in clinical care, research endeavors, and administrative tasks like health insurance claims.

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