Factor V Leiden ICD-10-CM Codes

Factor V Leiden ICD-10-CM Codes

Learn about the Factor V Leiden ICD-10-CM codes you can use through this guide.

By Matt Olivares on Jul 16, 2025.

Fact Checked by Gale Alagos.

Use Code

What ICD-10 codes are used for Factor V Leiden?

Factor V Leiden is a mutation of one of the clotting factors in the blood, leading to an increased risk of developing abnormal blood clots. The ICD-10-CM classification system provides specific codes for this genetic condition.

The key ICD-10-CM code for Factor V Leiden is D68.51 - Activated protein C resistance, as the Factor V Leiden mutation resists the effects of activated protein C.

Another related code that can be used is D68.59: Other primary thrombophilia. This code encompasses inherited thrombophilia conditions, including the Factor V Leiden mutation.

Which Factor V Leiden ICD codes are billable?

All of the aforementioned Factor V Leiden ICD-10 codes are valid and billable.

Clinical information

  • Factor V Leiden is the most prevalent inherited coagulation disorder in people of European ancestry.
  • This mutation causes a change in clotting factor V, making it less susceptible to being inactivated, leading to hypercoagulability.
  • Those with Factor V Leiden mutation have a heightened risk for venous thromboembolism, including deep vein thrombosis and pulmonary embolism.
  • While many carriers of the mutation never develop abnormal clots, they are at an increased risk, especially when combined with other clotting factors.
  • Treatment or preventive measures might involve anticoagulant medications, particularly if the individual has had previous clotting events.

Synonyms include

  • Activated protein C resistance
  • Factor V mutation
  • Genetic predisposition to clotting
  • Hereditary thrombophilia
  • Coagulation factor deficiency
  • Hereditary factor of thrombosis
  • Hereditary deficiency of other clotting factors
  • Homozygous factor V genes code for Factor V Leiden
  • Heterozygous factor V genes code for Factor V Leiden

Popular search terms for Factor V Leiden ICD-10-CM codes

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  • Factor V Leiden diagnosis codes
  • ICD-10 codes for Factor V Leiden

Related ICDs

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