F11.21 – Opioid dependence, in remission

F11.21 – Opioid dependence, in remission

Learn about ICD-10-CM code F11.21 for opioid dependence in remission, including clinical info, related codes, and more.

By Audrey Liz Perez on Aug 8, 2025.

Fact Checked by Gale Alagos.

Use Code

F11.21 diagnosis code: Opioid dependence, in remission

The ICD-10-CM code F11.21 denotes a diagnosis of opioid dependence that is currently in remission. This status indicates that the individual, previously diagnosed with opioid use disorder, is not exhibiting active symptoms and has maintained abstinence for a sustained period. Remission can be categorized as early remission (at least 3 months but less than 12 months) or sustained remission (12 months or longer).

This code does not signify a complete recovery but a period of managed or controlled symptoms. Understanding 'remission' in this context is crucial, as opioid dependence is often a chronic, relapsing condition.

Is F11.21 billable?

Yes, F11.21 is a billable code. This code can be used in a healthcare claim to represent a diagnosis and demonstrate the medical necessity of a patient's treatment or procedure.

Clinical information

  • Opioid dependence is a chronic condition characterized by compulsive opioid use, tolerance, and withdrawal symptoms.​
  • In remission signifies that the individual is not currently meeting the criteria for active opioid use disorder but remains at risk for relapse, especially with a history of opioid abuse.
  • Management may include continued medication-assisted treatment (e.g., methadone), counseling, and support groups to maintain remission.
  • Ongoing monitoring is essential to identify and manage opioid-induced disorders, including opioid induced psychotic disorder, opioid induced sleep disorder, opioid induced sexual dysfunction, mood disorders, sleep disorders, and other alcohol induced disorder.

Synonyms include:

  • Combined opioid and other drug dependence, in remission
  • Combined opioid with other drug dependence in remission
  • Drug dependence, combined, opioid and other drug
  • Opiod dependence in early full remission
  • Opioid dependence (moderate use disorder) on agonist therapy, in early remission
  • Opioid dependence (moderate use disorder) on agonist therapy, in sustained remission
  • Opioid dependence (moderate use disorder), in early remission
  • Opioid dependence (moderate use disorder), in sustained remission
  • Opioid dependence (severe use disorder) on agonist therapy, in early remission
  • Opioid dependence (severe use disorder) on agonist therapy, in sustained remission
  • Opioid dependence (severe use disorder), in early remission
  • Opioid dependence (severe use disorder), in sustained remission
  • Opioid dependence early full remission
  • Opioid dependence early partial remission
  • Opioid dependence in early partial remission
  • Opioid dependence in remission
  • Opioid dependence in sustained full remissio
  • Opioid dependence in sustained partial remission
  • Opioid dependence sustained full remission
  • Opioid dependence, moderate use, in early remission
  • Opioid dependence, moderate use, in sustained remission
  • Opioid dependence, moderate use, on agonist therapy, in early remission
  • Opioid dependence, moderate use, on agonist therapy, in sustained remission
  • Opioid dependence, severe use on agonist therapy, in early remission
  • Opioid dependence, severe use on agonist therapy, in sustained remission
  • Opioid dependence, severe use, in early remission
  • Opioid dependence, severe use, in sustained remission
  • Opioid depenedence sustained partial remission

Other ICD-10 codes commonly used for opioid dependence

  • F11.10 - Opioid Use, Unspecified
  • F11.20 - Opioid Dependence, Uncomplicated
  • F11.22 - Opioid Dependence with Intoxication
  • F11.23 - Opioid Dependence with Withdrawal
  • F11.24 - Opioid Dependence with Opioid-induced Mood Disorder
  • F11.28 – Opioid dependence with other opioid-induced disorder
  • F11.29 - Opioid Dependence with Other Opioid-induced Disorder
  • F11.90 - Opioid use, Unspecified with Unspecified Opioid-induced Disorder
  • F11.93 - Opioid use, Unspecified with Withdrawal

Commonly asked questions

No, remission does not equate to a cure. It means the individual is managing the condition and not actively using opioids.

Treatment generally involves a combination of medications (such as methadone or buprenorphine), counseling, and participation in support groups.

Yes, opioid dependence is often a chronic, relapsing condition. Even during remission, cravings and the risk of relapse can persist. Therefore, ongoing care is crucial.

Related ICDs

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