HCPCS Code Q5111: Injection, pegfilgrastim-cbqv (Udenyca®), biosimilar, 0.5 mg

Pegfilgrastim-cbqv is a granulocyte colony-stimulating factor used as a prophylactic subcutaneous injection to decrease the incidence of infection manifested by febrile neutropenia in patients receiving myelosuppressive chemotherapy for nonmyeloid malignancies.

The HCPCS code Q5111 specifically represents the injection of pegfilgrastim-cbqv biosimilar. Any cannula insertion performed during administration is generally reported separately, as the code covers only the substance, not the administration.

Coverage for Q5111 requires physician documentation supporting medical necessity, including diagnosis and treatment plan aligned with CMS and payer policies. Proper coding and adherence to clinical practice guidelines ensure effective claim processing and reimbursement.