HCPCS Code Q5110: Filgrastim-aafi Injection, Biosimilar

HCPCS Q5110 should be billed with the JA modifier for IV administration or the JB modifier for subcutaneous administration. The drug administration is included in the Q5110 billing with the proper modifier, so separate billing of an infusion CPT code like 96365 is not typically required or appropriate.

Bill one unit per microgram administered. Convert the dose to micrograms and enter that number as the units. Ensure the units on the claim match the documented dose and any waste is reflected with JW or JZ as required.

Filgrastim-aafi is not an FDA-approved or routine therapy for Crohn's disease. Research has explored colony-stimulating factors as investigational or off-label approaches in moderate to severe active Crohn’s disease, but Q5110 billing is focused on approved uses in neutropenia management and stem cell mobilization.