HCPCS Code Q5106: Injection, Epoetin Alfa-epbx, Biosimilar, (Retacrit) (For Non-ESRD use), 1000 Units

For a 3,000-unit dose of Retacrit®, billing units under HCPCS code Q5106 are calculated as 1 billing unit per 1,000 units; therefore, a 3,000-unit dose equates to 3 billing units.

Q5106 is indeed for epoetin alfa-epbx (Retacrit), which is an erythropoiesis-stimulating agent used to treat anemia, but it is not a chemotherapy drug; it is classified as a biologic used primarily for anemia related to chronic kidney disease and other conditions.

Billing Q5106 for Retacrit administration generally requires documentation of hemoglobin and hematocrit levels to support medical necessity, as these lab values justify the need for erythropoiesis-stimulating agents according to payer and CMS guidelines.