HCPCS Code J3489: Injection, Zoledronic Acid, 1 mg

Since each billing unit for HCPCS Code J3489 represents 1 mg, you should bill 3 units for a 2.5 mg dose. CMS requires rounding up to the next whole unit, and this must be dictated clearly in your notes to avoid claim denials.

Use the JW modifier on a separate claim line when any portion of the drug from a single-use vial is discarded. Use the JZ modifier when the entire vial is administered with no waste. Both modifiers are required by CMS for drugs like zoledronic acid to ensure billing accuracy.

For postmenopausal osteoporosis, the usual regimen is a 5 mg IV infusion once per year. Other conditions, such as Paget’s disease or cancer-related bone loss, may have different schedules. After treatment, patients may need rest for a few weeks, especially if they experience flu-like symptoms (e.g., fever, muscle aches). Since zoledronic acid works by protecting bone cartilage and reducing breakdown, frequency must always follow the treatment plan dictated by the physician.