HCPCS Code G0480: Drug Testing, Definitive, 1–7 Drug Class(es), Including Metabolites, Per Day, Excluding Immunoassays

Yes, but only if medically necessary and documentation supports why definitive testing was required in addition to presumptive testing.

Presumptive testing (e.g., immunoassay) screens for drug classes but may yield false positives/negatives. Meanwhile, definitive testing (e.g., LC/MS, GC/MS) confirms the presence of specific drugs/metabolites with higher accuracy.

Per CMS, a drug class is defined based on its pharmacological category, not individual analytes.