CPT Code 80307: Drug testing, presumptive, by using the instrument-chemistry analyzer

CPT code 80307 covers presumptive drug testing using an instrumented analyzer. Learn its uses, billing rules, and how it differs from definitive testing.

Use Code

Frequently asked questions

CPT 80307 is used to report presumptive drug testing performed using an instrument-based chemistry analyzer. It detects the presence or absence of drugs in a patient specimen, typically urine, and provides qualitative results without confirming specific substances.

CPT 80307 is for screening purposes only and provides preliminary results. In contrast, definitive drug testing identifies and quantifies specific drugs, usually through mass spectrometry, and is billed using different codes (80320–80377 or G0480–G0483 for Medicare).

Yes, but proper documentation is needed, and a modifier (such as modifier 59) may be required if multiple lab services are billed on the same date. Always verify payer guidelines to avoid denials for duplicate or bundled services.